In his work, Casco deals with the communications media, technical reproduc(t)ibility, popular and native culture, religiosity, and psychoanalysis. He holds a revisionist stance vis-á -vis the narrative of tradition and power present in different local, popular and religious, visual and iconographic, displays. Through subtle transgressions and a great deal of irony, he examines the apparent transparency and neutrality of different media such as television and photography. Casco constantly explores the limits between the so-called high culture and popular culture, and the tensions between official history and its "minor" documents. Casco reveals the imaginaries and cultural consumption of contexts shaped by post-colonial conditions, as is the case with Paraguay. His most recent series in progress El Retorno de los Brujos [The Return of the Sorcerers], made up of several chapters, contains in its first volume photographs concerning diplomatic activity during the Stroessner dictatorship that he acquired while shopping at a flea market and later manipulated digitally.

In this interview from 2007 theorist Ticio Escobar speaks to Casco about his interest in the political archive of Latin America and his interest in the tension between hi and low technologies.